Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.
Identifieur interne : 000113 ( Main/Exploration ); précédent : 000112; suivant : 000114Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.
Auteurs : Simone Gross [Allemagne] ; Andrea Fischer [Allemagne] ; Marco Rosati [Allemagne] ; Lara Matiasek [Allemagne] ; Daniele Corlazzoli [Italie] ; Rodolfo Cappello [Royaume-Uni] ; Laura Porcarelli [Italie] ; Tom Harcourt-Brown [Royaume-Uni] ; Konrad Jurina [Allemagne] ; Laurent Garosi [Royaume-Uni] ; Thomas Flegel [Allemagne] ; Pia Quitt [Allemagne] ; Jessica Molin [Allemagne] ; Velia-Isabel Huelsmeyer [Allemagne] ; Henning Schenk [Allemagne] ; Gualtiero Gandini [Italie] ; Kirsten Gnirs [France] ; Stéphane Blot [France] ; Aurélien Jeandel [France] ; Massimo Baroni [Italie] ; Shenja Loderstedt [Allemagne] ; Gianluca Abbiati [Italie] ; Carola Leithaeuser [Allemagne] ; Sabine Schulze [Allemagne] ; Marion Kornberg [Allemagne] ; Mark Lowrie [Royaume-Uni] ; Kaspar Matiasek [Allemagne]Source :
- Neuromuscular disorders : NMD [ 1873-2364 ] ; 2016.
Abstract
Recent views on Guillain-Barré syndrome (GBS) question the accuracy of classification into axonal and demyelinating subtypes that represent convergent neurophysiological phenotypes rather than immunological targets. Instead it has been proposed to clarify the primarily affected fibre subunit in nerve biopsies. As nerve biopsies rarely are part of routine work-up in human patients we evaluated tissues taken from companion animals affected by GBS-like polyradiculoneuropathy to screen for distribution of immune cells, targeted fibre components and segregating non-inflammatory lesions. We identified that immune responses were directed either at Schmidt-Lanterman clefts, the paranode-node complex or both. Based on infiltrative and non-inflammatory changes, four subtypes and/or stages were distinguished, some of which indicate localisation of primary target antigens while others represent convergent late stage pictures, as a consequence to epitope spreading. The impact of histological subtyping onto clinical management and prognosis remains to be evaluated in future clinical trials. Natural development and clinical manifestation of large animal dysimmune neuropathy may reflect human Guillain-Barré syndrome more accurately than experimental models and therefore provide complementary clues for translational research.
DOI: 10.1016/j.nmd.2016.08.015
PubMed: 27743643
Affiliations:
- Allemagne, France, Italie, Royaume-Uni
- Bavière, Berlin, District de Haute-Bavière, District de Leipzig, Latium, Saxe (Land), Île-de-France
- Berlin, Leipzig, Munich, Paris, Rome
- Université Louis-et-Maximilien de Munich
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xml:lang="fr">Allemagne</country><wicri:regionArea>Neurology Service, Tierklinik Lueneburg, Lueneburg</wicri:regionArea><wicri:noRegion>Lueneburg</wicri:noRegion><wicri:noRegion>Lueneburg</wicri:noRegion><wicri:noRegion>Lueneburg</wicri:noRegion></affiliation></author><author><name sortKey="Gandini, Gualtiero" sort="Gandini, Gualtiero" uniqKey="Gandini G" first="Gualtiero" last="Gandini">Gualtiero Gandini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Medical Science, University of Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Medical Science, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Gnirs, Kirsten" sort="Gnirs, Kirsten" uniqKey="Gnirs K" first="Kirsten" last="Gnirs">Kirsten Gnirs</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blot, Stephane" sort="Blot, Stephane" uniqKey="Blot S" first="Stéphane" last="Blot">Stéphane Blot</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort</wicri:regionArea><wicri:noRegion>Maisons Alfort</wicri:noRegion><wicri:noRegion>Maisons Alfort</wicri:noRegion></affiliation></author><author><name sortKey="Jeandel, Aurelien" sort="Jeandel, Aurelien" uniqKey="Jeandel A" first="Aurélien" last="Jeandel">Aurélien Jeandel</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort</wicri:regionArea><wicri:noRegion>Maisons Alfort</wicri:noRegion><wicri:noRegion>Maisons Alfort</wicri:noRegion></affiliation></author><author><name sortKey="Baroni, Massimo" sort="Baroni, Massimo" uniqKey="Baroni M" first="Massimo" last="Baroni">Massimo Baroni</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano</wicri:regionArea><wicri:noRegion>Monsummano</wicri:noRegion></affiliation></author><author><name sortKey="Loderstedt, Shenja" sort="Loderstedt, Shenja" uniqKey="Loderstedt S" first="Shenja" last="Loderstedt">Shenja Loderstedt</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Abbiati, Gianluca" sort="Abbiati, Gianluca" uniqKey="Abbiati G" first="Gianluca" last="Abbiati">Gianluca Abbiati</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Veterinaria Malpensa, Samarate, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Veterinaria Malpensa, Samarate</wicri:regionArea><wicri:noRegion>Samarate</wicri:noRegion></affiliation></author><author><name sortKey="Leithaeuser, Carola" sort="Leithaeuser, Carola" uniqKey="Leithaeuser C" first="Carola" last="Leithaeuser">Carola Leithaeuser</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt</wicri:regionArea><wicri:noRegion>Norderstedt</wicri:noRegion><wicri:noRegion>Norderstedt</wicri:noRegion><wicri:noRegion>Norderstedt</wicri:noRegion></affiliation></author><author><name sortKey="Schulze, Sabine" sort="Schulze, Sabine" uniqKey="Schulze S" first="Sabine" last="Schulze">Sabine Schulze</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Fuerstenwalde, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Fuerstenwalde</wicri:regionArea></affiliation></author><author><name sortKey="Kornberg, Marion" sort="Kornberg, Marion" uniqKey="Kornberg M" first="Marion" last="Kornberg">Marion Kornberg</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Trier</wicri:regionArea></affiliation></author><author><name sortKey="Lowrie, Mark" sort="Lowrie, Mark" uniqKey="Lowrie M" first="Mark" last="Lowrie">Mark Lowrie</name><affiliation wicri:level="1"><nlm:affiliation>Dovecote Veterinary Hospital, Castle Donington, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dovecote Veterinary Hospital, Castle Donington</wicri:regionArea><wicri:noRegion>Castle Donington</wicri:noRegion></affiliation></author><author><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><affiliation wicri:level="4"><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. 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wicri:level="4"><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Fischer, Andrea" sort="Fischer, Andrea" uniqKey="Fischer A" first="Andrea" last="Fischer">Andrea Fischer</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rosati, Marco" sort="Rosati, Marco" uniqKey="Rosati M" first="Marco" last="Rosati">Marco Rosati</name><affiliation wicri:level="4"><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Matiasek, Lara" sort="Matiasek, Lara" uniqKey="Matiasek L" first="Lara" last="Matiasek">Lara Matiasek</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Referral Service, Tierklinik Haar, Haar, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurology Referral Service, Tierklinik Haar, Haar</wicri:regionArea><wicri:noRegion>Haar</wicri:noRegion><wicri:noRegion>Haar</wicri:noRegion><wicri:noRegion>Haar</wicri:noRegion></affiliation></author><author><name sortKey="Corlazzoli, Daniele" sort="Corlazzoli, Daniele" uniqKey="Corlazzoli D" first="Daniele" last="Corlazzoli">Daniele Corlazzoli</name><affiliation wicri:level="3"><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Veterinaria Roma Sud, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cappello, Rodolfo" sort="Cappello, Rodolfo" uniqKey="Cappello R" first="Rodolfo" last="Cappello">Rodolfo Cappello</name><affiliation wicri:level="1"><nlm:affiliation>North Downs Specialist Referrals, Bletchingley, Surrey, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>North Downs Specialist Referrals, Bletchingley, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Porcarelli, Laura" sort="Porcarelli, Laura" uniqKey="Porcarelli L" first="Laura" last="Porcarelli">Laura Porcarelli</name><affiliation wicri:level="3"><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Veterinaria Roma Sud, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Harcourt Brown, Tom" sort="Harcourt Brown, Tom" uniqKey="Harcourt Brown T" first="Tom" last="Harcourt-Brown">Tom Harcourt-Brown</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Langford Veterinary Services, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Neurology, Langford Veterinary Services, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Jurina, Konrad" sort="Jurina, Konrad" uniqKey="Jurina K" first="Konrad" last="Jurina">Konrad Jurina</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Garosi, Laurent" sort="Garosi, Laurent" uniqKey="Garosi L" first="Laurent" last="Garosi">Laurent Garosi</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Referral Service, Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurology Referral Service, Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion</wicri:regionArea><wicri:noRegion>Higham Gobion</wicri:noRegion></affiliation></author><author><name sortKey="Flegel, Thomas" sort="Flegel, Thomas" uniqKey="Flegel T" first="Thomas" last="Flegel">Thomas Flegel</name><affiliation wicri:level="3"><nlm:affiliation>Neurology Unit, Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurology Unit, Department of Small Animal Medicine, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Quitt, Pia" sort="Quitt, Pia" uniqKey="Quitt P" first="Pia" last="Quitt">Pia Quitt</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Molin, Jessica" sort="Molin, Jessica" uniqKey="Molin J" first="Jessica" last="Molin">Jessica Molin</name><affiliation wicri:level="4"><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Huelsmeyer, Velia Isabel" sort="Huelsmeyer, Velia Isabel" uniqKey="Huelsmeyer V" first="Velia-Isabel" last="Huelsmeyer">Velia-Isabel Huelsmeyer</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schenk, Henning" sort="Schenk, Henning" uniqKey="Schenk H" first="Henning" last="Schenk">Henning Schenk</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Tierklinik Lueneburg, Lueneburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurology Service, Tierklinik Lueneburg, Lueneburg</wicri:regionArea><wicri:noRegion>Lueneburg</wicri:noRegion><wicri:noRegion>Lueneburg</wicri:noRegion><wicri:noRegion>Lueneburg</wicri:noRegion></affiliation></author><author><name sortKey="Gandini, Gualtiero" sort="Gandini, Gualtiero" uniqKey="Gandini G" first="Gualtiero" last="Gandini">Gualtiero Gandini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Medical Science, University of Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Medical Science, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Gnirs, Kirsten" sort="Gnirs, Kirsten" uniqKey="Gnirs K" first="Kirsten" last="Gnirs">Kirsten Gnirs</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blot, Stephane" sort="Blot, Stephane" uniqKey="Blot S" first="Stéphane" last="Blot">Stéphane Blot</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort</wicri:regionArea><wicri:noRegion>Maisons Alfort</wicri:noRegion><wicri:noRegion>Maisons Alfort</wicri:noRegion></affiliation></author><author><name sortKey="Jeandel, Aurelien" sort="Jeandel, Aurelien" uniqKey="Jeandel A" first="Aurélien" last="Jeandel">Aurélien Jeandel</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort</wicri:regionArea><wicri:noRegion>Maisons Alfort</wicri:noRegion><wicri:noRegion>Maisons Alfort</wicri:noRegion></affiliation></author><author><name sortKey="Baroni, Massimo" sort="Baroni, Massimo" uniqKey="Baroni M" first="Massimo" last="Baroni">Massimo Baroni</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano</wicri:regionArea><wicri:noRegion>Monsummano</wicri:noRegion></affiliation></author><author><name sortKey="Loderstedt, Shenja" sort="Loderstedt, Shenja" uniqKey="Loderstedt S" first="Shenja" last="Loderstedt">Shenja Loderstedt</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Abbiati, Gianluca" sort="Abbiati, Gianluca" uniqKey="Abbiati G" first="Gianluca" last="Abbiati">Gianluca Abbiati</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Veterinaria Malpensa, Samarate, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Veterinaria Malpensa, Samarate</wicri:regionArea><wicri:noRegion>Samarate</wicri:noRegion></affiliation></author><author><name sortKey="Leithaeuser, Carola" sort="Leithaeuser, Carola" uniqKey="Leithaeuser C" first="Carola" last="Leithaeuser">Carola Leithaeuser</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt</wicri:regionArea><wicri:noRegion>Norderstedt</wicri:noRegion><wicri:noRegion>Norderstedt</wicri:noRegion><wicri:noRegion>Norderstedt</wicri:noRegion></affiliation></author><author><name sortKey="Schulze, Sabine" sort="Schulze, Sabine" uniqKey="Schulze S" first="Sabine" last="Schulze">Sabine Schulze</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Fuerstenwalde, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Fuerstenwalde</wicri:regionArea></affiliation></author><author><name sortKey="Kornberg, Marion" sort="Kornberg, Marion" uniqKey="Kornberg M" first="Marion" last="Kornberg">Marion Kornberg</name><affiliation wicri:level="1"><nlm:affiliation>Small Animal Clinic Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Small Animal Clinic Trier</wicri:regionArea></affiliation></author><author><name sortKey="Lowrie, Mark" sort="Lowrie, Mark" uniqKey="Lowrie M" first="Mark" last="Lowrie">Mark Lowrie</name><affiliation wicri:level="1"><nlm:affiliation>Dovecote Veterinary Hospital, Castle Donington, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dovecote Veterinary Hospital, Castle Donington</wicri:regionArea><wicri:noRegion>Castle Donington</wicri:noRegion></affiliation></author><author><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><affiliation wicri:level="4"><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: kaspar.matiasek@neuropathologie.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><series><title level="j">Neuromuscular disorders : NMD</title><idno type="eISSN">1873-2364</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent views on Guillain-Barré syndrome (GBS) question the accuracy of classification into axonal and demyelinating subtypes that represent convergent neurophysiological phenotypes rather than immunological targets. Instead it has been proposed to clarify the primarily affected fibre subunit in nerve biopsies. As nerve biopsies rarely are part of routine work-up in human patients we evaluated tissues taken from companion animals affected by GBS-like polyradiculoneuropathy to screen for distribution of immune cells, targeted fibre components and segregating non-inflammatory lesions. We identified that immune responses were directed either at Schmidt-Lanterman clefts, the paranode-node complex or both. Based on infiltrative and non-inflammatory changes, four subtypes and/or stages were distinguished, some of which indicate localisation of primary target antigens while others represent convergent late stage pictures, as a consequence to epitope spreading. The impact of histological subtyping onto clinical management and prognosis remains to be evaluated in future clinical trials. Natural development and clinical manifestation of large animal dysimmune neuropathy may reflect human Guillain-Barré syndrome more accurately than experimental models and therefore provide complementary clues for translational research.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Haute-Bavière</li><li>District de Leipzig</li><li>Latium</li><li>Saxe (Land)</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Leipzig</li><li>Munich</li><li>Paris</li><li>Rome</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Gross, Simone" sort="Gross, Simone" uniqKey="Gross S" first="Simone" last="Gross">Simone Gross</name></region><name sortKey="Fischer, Andrea" sort="Fischer, Andrea" uniqKey="Fischer A" first="Andrea" last="Fischer">Andrea Fischer</name><name sortKey="Flegel, Thomas" sort="Flegel, Thomas" uniqKey="Flegel T" first="Thomas" last="Flegel">Thomas Flegel</name><name sortKey="Huelsmeyer, Velia Isabel" sort="Huelsmeyer, Velia Isabel" uniqKey="Huelsmeyer V" first="Velia-Isabel" last="Huelsmeyer">Velia-Isabel Huelsmeyer</name><name sortKey="Jurina, Konrad" sort="Jurina, Konrad" uniqKey="Jurina K" first="Konrad" last="Jurina">Konrad Jurina</name><name sortKey="Kornberg, Marion" sort="Kornberg, Marion" uniqKey="Kornberg M" first="Marion" last="Kornberg">Marion Kornberg</name><name sortKey="Leithaeuser, Carola" sort="Leithaeuser, Carola" uniqKey="Leithaeuser C" first="Carola" last="Leithaeuser">Carola Leithaeuser</name><name sortKey="Loderstedt, Shenja" sort="Loderstedt, Shenja" uniqKey="Loderstedt S" first="Shenja" last="Loderstedt">Shenja Loderstedt</name><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><name sortKey="Matiasek, Lara" sort="Matiasek, Lara" uniqKey="Matiasek L" first="Lara" last="Matiasek">Lara Matiasek</name><name sortKey="Molin, Jessica" sort="Molin, Jessica" uniqKey="Molin J" first="Jessica" last="Molin">Jessica Molin</name><name sortKey="Quitt, Pia" sort="Quitt, Pia" uniqKey="Quitt P" first="Pia" last="Quitt">Pia Quitt</name><name sortKey="Rosati, Marco" sort="Rosati, Marco" uniqKey="Rosati M" first="Marco" last="Rosati">Marco Rosati</name><name sortKey="Schenk, Henning" sort="Schenk, Henning" uniqKey="Schenk H" first="Henning" last="Schenk">Henning Schenk</name><name sortKey="Schulze, Sabine" sort="Schulze, Sabine" uniqKey="Schulze S" first="Sabine" last="Schulze">Sabine Schulze</name></country><country name="Italie"><region name="Latium"><name sortKey="Corlazzoli, Daniele" sort="Corlazzoli, Daniele" uniqKey="Corlazzoli D" first="Daniele" last="Corlazzoli">Daniele Corlazzoli</name></region><name sortKey="Abbiati, Gianluca" sort="Abbiati, Gianluca" uniqKey="Abbiati G" first="Gianluca" last="Abbiati">Gianluca Abbiati</name><name sortKey="Baroni, Massimo" sort="Baroni, Massimo" uniqKey="Baroni M" first="Massimo" last="Baroni">Massimo Baroni</name><name sortKey="Gandini, Gualtiero" sort="Gandini, Gualtiero" uniqKey="Gandini G" first="Gualtiero" last="Gandini">Gualtiero Gandini</name><name sortKey="Porcarelli, Laura" sort="Porcarelli, Laura" uniqKey="Porcarelli L" first="Laura" last="Porcarelli">Laura Porcarelli</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Cappello, Rodolfo" sort="Cappello, Rodolfo" uniqKey="Cappello R" first="Rodolfo" last="Cappello">Rodolfo Cappello</name></noRegion><name sortKey="Garosi, Laurent" sort="Garosi, Laurent" uniqKey="Garosi L" first="Laurent" last="Garosi">Laurent Garosi</name><name sortKey="Harcourt Brown, Tom" sort="Harcourt Brown, Tom" uniqKey="Harcourt Brown T" first="Tom" last="Harcourt-Brown">Tom Harcourt-Brown</name><name sortKey="Lowrie, Mark" sort="Lowrie, Mark" uniqKey="Lowrie M" first="Mark" last="Lowrie">Mark Lowrie</name></country><country name="France"><region name="Île-de-France"><name sortKey="Gnirs, Kirsten" sort="Gnirs, Kirsten" uniqKey="Gnirs K" first="Kirsten" last="Gnirs">Kirsten Gnirs</name></region><name sortKey="Blot, Stephane" sort="Blot, Stephane" uniqKey="Blot S" first="Stéphane" last="Blot">Stéphane Blot</name><name sortKey="Jeandel, Aurelien" sort="Jeandel, Aurelien" uniqKey="Jeandel A" first="Aurélien" last="Jeandel">Aurélien Jeandel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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